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Brain oxygen, CO2, pH, and temperature monitoring: evaluation in the feline brain.Neurosurgery. ( b) On supine abdomi-nal radiograph, this gas collection ( arrow) seems to have a constantrelationship to the stomach with changes in the patient’s position. This was due to the manifestations of the disease as well as thefact that Haemophilia B is one of the most well characterised rare diseases whereproof of principle and proof of concept biomarkers (plasma Factor IX levels andrecombinant protein consumption) correlate very well with the disease outcome(need for prophylaxis as an indication of the severity of disease) [ 33].

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